The 5-MeO group includes the following 5-MeO-AMT, 5-MeO-DALT, 5-MeO-DET, 5-MeO-DMT, 5-MeO-DIPT, 5-MeO-MIPT, and others. The most commonly used 5-MeO chemicals are 5-MeO-AMT, 5-MeO-DALT and 5-MeO-DMT. 5-MeO-DMT is a naturally occurring psychedelic present in numerous plants and in the venom of the Bufo alvarius toad. It is found in some traditional S. American shamanic snuffs used in rituals and sometimes in ayahuasca brews. 5-MeO DALT (or N, N-diallylmethoxytryptamine), is a synthetic, psychedelic drug belonging to the ‘tryptamine’ class which includes drugs such as DMT. It was first synthesised by Shulgin in 2004 as an analogue of DMT and produces similar stimulant and spiritual (entheogenic) effects. There have been no reported deaths associated with taking 5-MeO DALT by itself. In July 2010, a man in his 20s was hit and killed by a heavy goods vehicle on a UK motorway after having taken 350mg of 5-Meo DALT (more than 10 times a typical dose) and drinking alcohol earlier in the evening.
5-MeO-DMT (5-methoxy-N,N-dimethyltryptamine) or O-methyl-bufotenin is a psychedelic of the tryptamine class. It is found in a wide variety of plant species, and at least one toad species, the Sonoran Desert toad. Like its close relatives DMT and bufotenin (5-HO-DMT), it has been used as an entheogen in South America. Slang terms include Five-methoxy, The power, and Toad venom.
NOTE: despite the similarities in name and some of the effects, 5-MeO-DMT should not be confused with DMT.
It may have anti-anxiety and anti-depressant effects.
Religious use : The Church of the Tree of Life, founded in California in 1971 by John Mann but now defunct, declared the use of 5-MeO-DMT to be a sacrament. From approximately 1971 to the late 1980s, 5-MeO-DMT was discreetly available to its members. Between 1970 and 1990, smoking of 5-MeO-DMT on parsley was probably one of the two most common forms of ingestion in the United States.
5-MeO-DMT is being developed and evaluated for potential therapeutic effects in patients suffering from Treatment-Resistant Depression (TRD). Thus far, GH Research has sponsored a completed study in healthy volunteers and an ongoing study in TRD patients.
The 5-Methoxy-N,N-dimethyltryptamine (5–MeO–DMT) is a naturally occurring compound capable of inducing a powerful psychedelic state. Recently, it has been suggested that DMT analogs may be used in the treatment of mood disorders.